Figure 5.

A representation of the regional sensitivities in the heart to high potassium, and the effects of hyperkalemia, ischemia (acidosis), and hypothermia on the ventricular action potential. The effects were obtained from the empirical data in rabbit ventricle and the ventricular modeling studies of Shaw and Rudy (1997) and Cimponeriu et al. (2001). The effects of hypothermia to prolong the action potential are from West et al. (1959), Lathrop et al. (1998) and Coraboeuf et al. (1998; Aoki et al., 1994).