Table 2B.
Clinical Characteristics of Recently Reported De Novo Colorectal Cancer in Liver Transplant Recipients
| Study | Number of Patients | Treatment | Location | Stage | Outcome |
|---|---|---|---|---|---|
| Haagsma et al4 | 3 | Left colectomy with 9 months of 5-FU; another with 10 months of 5-FU | – | 2 Metastases | 1 Cancer-related death (metastasis) |
| Kelly et al12 | 3 | Colectomy; 1 patient treated with chemotherapy | – | – | – |
| Jain et al15 | 4 | Surgery | 2 Right-sided, 1 rectum, 1 sigmoid | T3 N0 (3 cases) and T3 N1 | 2 Cancer-related deaths |
| Vera et al18 | 7 | – | – | – | – |
| Vera et al18 | 8 | – | 3 Right-sided, 3 transverse, 2 left-sided | 3 Stage I, 1 stage II, 2 stage III, 2 stage IV | 3 Cancer-related deaths (4, 21, and 7 months); 1 chronic rejection |
| Frezza et al19 | 3 | Surgery | Right, left, rectum | T3 N2 M1; T4 N1; T3 N0 (rectum) | Alive |
| Silva et al20 | 18 | – | – | – | – |
| Oo et al21 | 18 | – | – | – | 2 Cancer-related deaths |
| Fabia et al22 | 1 | Hemicolectomy | – | – | 2 Years disease free |
| Fabia et al22 | 4 | Colectomy | – | – | 2 Developed metastasis 1–2 years after surgery; 2 deaths |
| Sanchez et al23 | 7 | – | 6 Colon, 1 rectal | – | – |
| Bleday et al26 | 3 | Colectomy; (1 with history of subtotal and ileorectal) | Hepatic flexure, rectosigmoid junction | 2 Dukes B | – |
| Loftus et al33 | 3 | Colectomy | – | – | – |
| Peyrin-Biroulet et al43 | 1 | Coloproctectomy; chemotherapy planned but not reported | Cecum, right side | T4 N2 M0 (19/126 LNs) | – |
| Parikshak et al47 | 2 | Colectomy; local excision | Sigmoid (2 patients) | Stages I, II | – |
| MacLean et al48 | 4 | Colectomy | Rectum, ascending, cecum, splenic flexure | – | – |
| Goss et al49 | 6 | – | – | 4 Dukes A, 2 Dukes C | – |
| Narumi et al50 | 1 | Proctocolectomy; irradiation | Rectal | Dukes B | Cancer-related death |
| Papaconstantinou et al51 | 27 | – | – | – | – |
Dashes indicate data not available.
Abbreviation: LNs = lymph nodes