Table 2.
Study characteristics and unadjusted odds ratio estimates of Hodgkin lymphoma for ever cigarette smokers versus never smokers and associated 95% confidence limits, according to substudy
| Data provider (substudy) | EBV status | Histology | Never smokers (cases/controls) | Ever cigarette smokers (cases/controls) | OR (95% CI) |
|---|---|---|---|---|---|
| Chang (Connecticut) | Yes | Yes | 85/131 | 132/154 | 1.40 (0.97–2.02) |
| Chang (Massachusetts) | Yes | Yes | 129/170 | 154/159 | 1.34 (0.97–1.87) |
| Cozen (USA) | No | Yes | 56/59 | 30/28 | 1.14 (0.41–3.15) |
| Dal Maso (Italy 1984–1991) | No | No | 79/469 | 77/680 | 0.74 (0.51–1.08) |
| Dal Maso (Italy 1998-2002) | No | Yes | 24/182 | 38/317 | 1.79 (0.90–3.57) |
| Epilymph (Spain) | Yes | Yes | 20/297 | 36/326 | 1.29 (0.68–2.47) |
| Epilymph (other centres) | No | Yes | 117/835 | 151/1053 | 1.03 (0.79–1.34) |
| Glaser (Northern California) | Yes | Yes | 181/186 | 129/139 | 0.99 (0.72–1.36) |
| Hjalgrim (Denmark) | Yes | Yes | 91/409 | 147/722 | 1.63 (1.16–2.30) |
| Hjalgrim (Sweden) | Yes | Yes | 196/952 | 137/1002 | 1.08 (0.83–1.42) |
| Kane (England)a | Yes | Yes | 105/111 | 145/123 | 1.43 (0.97–2.10) |
| Miligi (Italy) | No | Yes | 160/809 | 200/954 | 0.97 (0.75–1.25) |
| Monnereau (France) | No | Yes | 54/150 | 85/261 | 0.89 (0.61–1.30) |
| Spinelli (Canada) | No | Yes | 101/393 | 161/945 | 1.10 (0.83–1.44) |
| Zahm (Midwest) | No | Yes | 63/925 | 122/1337 | 1.31 (0.94–1.83) |
| Pooled dataset | – | – | 1461/6078 | 1744/8200 | 1.13 (1.02–1.26)b |
aNot all cases were matched to a control. These excess cases only contributed to the case-series analyses.
bI2 is 6.