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. Author manuscript; available in PMC: 2013 Aug 28.
Published in final edited form as: Neurosci Med. 2012 Sep 25;3(3):294–305. doi: 10.4236/nm.2012.33034

Fig 5.

Fig 5

Effect of GSNO on pain threshold of naïve and CEC rats. Naive rats were treated either with saline (vehicle) or GSNO after measuring the baseline pain threshold using AM (A) as well as DPA (B). Pain threshold was measured at 1, 2, 4, 6 and 24 hours after the treatments. GSNO-mediated increase in pain threshold was noted 6 h after administration. However, no significant effect was not seen at 24 h. Data are presented a mean ±SD for n=8 in each group. ** p<0.01 vs. vehicle. Effect of GSNO on pain threshold of CEC animals was given in C & D. Pain threshold was measured with AM. Base line represents the pain threshold of rats before CEC. There was a significant difference in pain threshold between the vehicle and sham groups on all days tested. However, no significant difference was observed between sham and GSNO groups from day 2. Fig 2D shows pain threshold of CEC rats measured with DPA. Vehicle animals showed significantly lesser pain threshold on all days tested compared with the base line. Pain threshold of GSNO animals was not significantly different from the baseline on all days tested except day 2. Data are presented as mean ± SD for n=8 in each group. *p<0.05, **p<0.005 vs. vehicle, # p<0.05: vs. baseline.