Table 2.
Distribution of MTHFR C677T genotypes in family-based migraine case and unrelated control groups.
| Genotypes | Alleles | |||||
| Group | C/C | C/T | T/T | N (genotypes) | C | T |
| Related-MO+MA | 112 (35%) | 167 (52%) | 40 (13%) | 319 | 391 (61%) | 247 (39%) |
| Related MA* | 84 (34%) | 132 (53%) | 31 (13%) | 247 | 300 (61%) | 194 (39%) |
| Unrelated Control | 117 (43%) | 129 (48%) | 23 (9%) | 269 | 363 (67%) | 175 (33%) |
*genotype distribution comparison (Trend χ2 = 4.25, P = 0.039 adjusted for relatedness in affecteds), T/T genotype vs C/C (OR = 1.88, 95% CI: 1.01 – 3.52).