Responses to cocaine (5 mg/kg iv) in vascular and mixed responders. The mean arterial pressure (MAP), cardiac output (CO), systemic vascular resistance (SVR), and stroke volume (SV) following cocaine administration are depicted. #Significant differences exist between vascular and mixed responders in the changes in CO, SVR, and SV changes after cocaine administration (P < 0.05). No significant differences in heart rate changes after cocaine administration were observed between groups.