Fig. 6.

Effects of microinjection of losartan (20 ng) into the MnPO on hemodynamic responses to cocaine (5 mg/kg iv). Hemodynamic responses are shown for vascular responders and mixed responders following cocaine administration alone and for cocaine administration following losartan (Los) pretreatment. #Significant differences (P < 0.05) between vascular and mixed responders exist in the changes seen in MAP, CO, and SVR. *Losartan pretreatment produced significant differences (P < 0.05) among vascular responders in the changes seen in CO, SVR, and SV after cocaine administration. Losartan did not produce any differences in heart rate changes.