Fig. 8.

Effects of microinjection of MK-801 (20 nmol) into the MnPO on hemodynamic responses to cocaine (5 mg/kg iv). Hemodynamic responses are shown for vascular responders and mixed responders following cocaine administration alone and for cocaine administration following MK-801 pretreatment. #Significant differences (P < 0.05) between vascular and mixed responders exist in the changes seen in CO and SVR. *MK-801 pretreatment produced significant differences (P < 0.05) among vascular responders in the changes seen in MAP, CO, and SVR.