Table 2.

Effects of drug treatment alone immediately before cocaine administration

Stimulus	Class	No.	Mean AP, mmHg	Δ MAP, mmHg	HR, beats/min	Δ HR, beats/min	CO, kHz	Δ CO, kHz	Δ SVR, %	Δ SV, %
Muscimol	MR	6	115±4	−1.0±1.5	417±9	−4±8	−2.7±0.1	−4.1±2	3.6±2.8	−2.9±3.6
	VR	7	118±7	−0.4±0.5	409±12	7±4	−2.9±0.1	0.1±2	−0.3±2.3	−1.5±2.3
Losartan	MR	5	120±8	−0.2±3.1	428±16	−14±5	−3.1±0.1	−3.5±1.9	3.6±2.8	−0.2±2.6
	VR	7	122±3	−0.4±2.3	425±12	−4±7	−3.0±0.2	−6.7±2.4*	6.9±2.9*	−5.5±3.4
MK-801	MR	7	123±7	−0.5±1.0	377±21	−11±9	−2.5±0.2	1.6±1.4	−2.2±2.3	5.5±2.9
	VR	6	118±4	0.8±3.2	394±28	−4±3	−2.8±0.1	−1.4±2.1	2.4±2.1	−0.6±2.5

Values are means ± SE. No. is number of rats studied.

^*Significant difference with treatment alone (P < 0.05).