Table 3.
Prevaccination | Days after last vaccination | ||||||
---|---|---|---|---|---|---|---|
Days | 0 | 4 | 8 | 14 | 28 | 180 | 365 |
Assay and Group (or day of vaccination) | GMT (CI) for PRNT/ELISA, Mean (SD) for IFN-γ no. positive/no. tested (%) (CI of %) | ||||||
BN PRNT | |||||||
0,7 | 7.5 (-, -) | 8.4 (7.2, 9.7) | 10.0 (8.3, 12.2) | 10.8 (9.0, 12.9) | 9.9 (8.6, 11.3) | 8.2 (7.7, 8.8) | 8.1 (7.7, 8.6) |
0/60 (0.0) | 4/59 (6.8) | 14/59 (23.7) | 23/59 (39.0) | 19/58 (32.8) | 8/59 (13.6) | 7/59 (11.9) | |
(0.0, 6.0) | (1.9, 16.5) | (13.6, 36.6) | (26.5, 52.6) | (21.0, 46.3) | (6.0, 25.0) | (4.9, 22.9) | |
0,28 | 7.5 (-, -) | 8.4 (7.9, 9.0) | 21.0 (15.8, 27.8) | 30.2 (22.1, 41.1) | 17.2 (13.6, 21.7) | 8.7 (8.1, 9.3) | 8.8 (8.2, 9.5) |
0/67 (0.0) | 11/64 (17.2) | 44/63 (69.8) | 52/63 (82.5) | 47/64 (73.4) | 13/63 (20.6) | 14/60 (23.3) | |
(0.0, 5.4) | (8.9, 28.7) | (57.0, 80.8) | (70.9, 90.9) | (60.9, 83.7) | (11.5, 32.7) | (13.4, 36.0) | |
0 | 7.5 (-, -) | 7.5 (-, -) | 7.5 (-, -) | 8.1 (7.7, 8.6) | 8.5 (7.9, 9.1) | 7.8 (7.5, 8.1) | 7.9 (7.3, 8.6) |
0/63 (0.0) | 0/63 (0.0) | 0/63 (0.0) | 7/62 (11.3) | 11/62 (17.7) | 3/61 (4.9) | 2/61 (3.3) | |
(0.0, 5.7) | (0.0, 5.7) | (0.0, 5.7) | (4.7, 21.9) | (9.2, 29.5) | (1.0, 13.7) | (0.4, 11.3) | |
SLU PRNT | |||||||
0,7 | 2.0 (-,-) | 7.2 (4.9, 10.6) | 18.6 (12.6, 27.6) | 27.4 (19.1, 39.3) | 25.2 (17.8, 35.5) | 6.3 (4.8,8.1) | 6.6 (5.0, 8.7) |
0/60 (0) | 13/59 (22.0) | 31/59 (52.5) | 35/59 (59.3) | 33/58 (56.9) | 7/59 (11.9) | 10/59 (16.9) | |
(0.0, 6.0) | (12.3, 34.7) | (39.1, 65.7) | (45.7, 71.9) | (43.2, 69.8) | (4.9, 22.9) | (8.4, 29.0) | |
0,28 | 2.0 (-,-) | 10.4 (7.8, 13.9) | 119.6 (79.5, 179.9) | 212.2 (146.6, 307.2) | 119.7 (86.0, 166.7) | 13.9 (10.6, 18.2) | 10.8 (8.2, 14.2) |
0/68 (0) | 22/64 (34.4) | 54/63 (85.7) | 60/63 (95.2) | 60/64 (93.8) | 26/63 (41.3) | 20/60 (33.3) | |
(0.0, 5.3) | (22.9, 47.3) | (74.6, 93.3) | (86.7, 99.0) | (84.8, 98.3) | (29.0, 54.4) | (21.7, 46.7) | |
0 | 2.0 (-,-) | 2.0 (-, -) | 2.0 (2.0, 2.1) | 7.0 (5.3, 9.3) | 8.5 (6.6, 10.9) | 4.2(3.3,5.2) | 4.1 (3.2,5.3) |
0/63 (0) | 0/63 (0) | 0/63 (0) | 12/62 (19.4) | 11/62 (17.7) | 6/61 (9.8) | 5/61 (8.2) | |
(0.0, 5.7) | (0.0, 5.7) | (0.0. 5.7) | (10.4, 31.4) | (9.2, 29.5) | (3.7, 20.2) | (2.7, 18.1) | |
BN ELISA | |||||||
0,7 | 25.3 (24.7, 25.9) | 43.1 (35.6, 52.2) | 74.0 (60.5, 90.7) | 108.7 (87.7, 134.8) | 99.3 (81.0, 121.7) | 37.6 (32.7. 43.3) | 40.6 (33.1, 49.9) |
1/60 (1.7) | 30/59 (50.8) | 48/59 (81.4) | 54/59 (91.5) | 54/58 (93.1) | 27/59 (45.8) | 26/59 (44.1) | |
(0.0, 8.9) | (37.5, 64.1) | (69.1, 90.3) | (81.3, 97.2) | (83.3, 98.1) | (32.7, 59.2) | (31.2, 57.6) | |
0,28 | 26.3 (24.6, 28.2) | 63.7 (52.2, 77.8) | 269.2 (195.1, 371.4) | 501.7 (364.1, 691.3) | 311.8 (231.7, 419.7) | 57.4 (47.8, 68.9) | 50.3 (41.9, 60.2) |
3/67 (4.5) | 46/64 (71.9) | 57/63 (90.5) | 61/63 (96.8) | 60/64 (93.8) | 46/63 (73.0) | 37/60 (61.7) | |
(0.9, 12.5) | (59.2, 82.4) | (80.4, 96.4) | (89.0, 99.6) | (84.8, 98.3) | (60.3, 83.4) | (48.2, 73.9) | |
0 | 25.8 (24.9, 26.8) | 25.8 (24.9, 26.8) | 27.6 (25.6, 29.8) | 56.6 (47.0, 68.1) | 63.8 (50.2, 81.1) | 35.3 (29.1, 42.9) | 35.1 (30.2, 40.8) |
3/63 (4.8) | 3/63 (4.8) | 7/63 (11.1) | 44/62 (71.0) | 46/62 (74.2) | 20/61 (32.8) | 22/61 (36.1) | |
(1.0, 13.3) | (1.0, 13.3) | (4.6, 21.6) | (58.1, 81.8) | (61.5, 84.5) | (21.3, 46.0) | (24.2, 49.4) | |
SLU ELISA | |||||||
0,7 | 50.0 (-, -) | 54.0 (46.3, 62.9) | 54.8 (47.1, 63.7) | 60.5 (51.0, 71.7) | 59.3 (52.7, 66.6) | 54.0 (48.7, 59.9) | 60.0 (50.4, 71.5) |
0/60 (0.0) | 1/59 (1.7) | 2/59 (3.4) | 7/59 (11.9) | 8/58 (13.8) | 3/59 (5.1) | 6/59 (10.2) | |
(0.0, 6.0) | (0.0, 9.1) | (0.4, 11.7) | (4.9, 22.9) | (6.1, 25.4) | (1.1, 14.1) | (3.8, 20.8) | |
0,28 | 50.0 (-, -) | 54.4 (50.4, 58.8) | 280.1 (203.9, 384.7) | 510.9 (373.0, 699.7) | 319.6 (244.2, 418.3) | 60.4 (54.1, 67.5) | 59.3 (53.8, 65.4) |
0/67 (0.0) | 5/64 (7.8) | 47/63 (74.6) | 55/63 (87.3) | 54/64 (84.4) | 11/63 (17.5) | 11/60 (18.3) | |
(0.0, 5.4) | (2.6, 17.3) | (62.1, 84.7) | (76.5, 94.4) | (73.1, 92.2) | (9.1, 29.1) | (9.5, 30.4) | |
0 | 50.0 (-, -) | 50.0 (-, -) | 50.0 (-, -) | 50.0 (-, -) | 52.7 (50.0, 55.5) | 50.0 (-, -) | 50.8 (49.2, 52.5) |
0/63 (0.0) | 0/63 (0.0) | 0/63 (0.0) | 0/62 (0.0) | 4/62 (6.5) | 0/61 (0.0) | 1/63 (1.6) | |
(0.0, 5.7) | (0.0, 5.7) | (0.0, 5.7) | (0.0, 5.8) | (1.8, 15.7) | (0.0, 5.9) | (0.0, 8.8) | |
IFN-γ ELISPOT | |||||||
Days | 0 | 4 | 8 | 14 | 28 | 180 | 365 |
0,7 | 0.55 (0.95) | 348.51 (287.41) | 305.85 (279.13) | 279.20 (250.48) | 173.79 (211.90) | 96.68 (116.38) | 58.97 (81.12) |
0/59 (0.0) | 50/58 (86.2) | 48/59 (81.4) | 46/57 (80.7) | 37/59 (62.7) | 31/57 (54.4) | 25/59 (42.4) | |
(0.0, 6.1) | (74.6, 93.9) | (69.1, 90.3) | (68.1, 90.0) | (49.1, 75.0) | (40.7, 67.6) | (29.6, 55.9) | |
0,28 | 6.40 (39.32) | 97.95 (156.58) | 202.34 (243.37) | 243.66 (274.06) | 185.66 (185.83) | 121.04 (113.05) | 73.14 (79.75) |
1/65 (1.5) | 26/63 (41.3) | 42/62 (67.7) | 42/67 (67.7) | 38/61 (62.3) | 41/62 (66.1) | 26/59 (44.1) | |
(0.0, 8.3) | (29.0, 54.4) | (54.7, 79.1) | (54.7, 79.1) | (49.0, 74.4) | (53.0, 77.7) | (31.2, 57.6) | |
0 | 3.33 (17.62) | 3.84 (16.34) | 58.50 (86.54) | 297.62 (262.28) | 117.30 (178.92) | 45.20 (44.31) | 27.53 (39.30) |
1/63 (1.6) | 1/63 (1.6) | 20/63 (31.7) | 51/62 (82.3) | 27/62 (43.5) | 20/61 (32.8) | 8/59 (13.6) | |
(0.0, 8,.5) | (0.0, 8.5) | (20.6, 44.7) | (70.5, 90.8) | (31.0, 56.7) | (21.3, 46.0) | (6.0, 25.0) |