Table 3.
Characteristics of LOS subjects according to age of diagnosis.
| Adult-Onset SLE (n= 859) | Childhood-OnsetSLE (n= 98) | p value | |
|---|---|---|---|
| Demographic Characteristics | |||
| Age, mean (range), y* | 52 (23-99) | 33 (19-63) | |
| Male, % | 8 | 15.5 | 0.018 |
| Ethnicity, % | |||
| Non-Caucasian | 32 | 51 | 0.0009 |
| Education, %* | 0.05 | ||
| Some/Graduated High School | 17 | 15 | |
| Some College/Trade School | 46 | 36 | |
| College degree or Higher | 37 | 49 | |
| Below Poverty, %§ | 12.2 | 13.4 | 0.7 |
| Insurance§ | 0.04 | ||
| Employer-based | 69 | 74 | |
| Medicare | 24 | 16 | |
| Medicaid | 7 | 10 | |
| SLE Characteristics* | |||
| Age at diagnosis, median (range), y | 35 (18-87) | 15 (2-17) | <0.0001 |
| Disease duration, mean (range), y | 16.5 (1-50) | 19.5 (4-51) | <0.0001 |
| Organ Manifestations, % | |||
| ACR Renal Criteria | 23.6 | 56.1 | <0.0001 |
| End Stage Renal Disease | 8.4 | 21.4 | <0.0001 |
| Cardiovascular disease† | 28 | 24 | NS |
| Disease Activity, | |||
| SLAQ score, mean (SD)‡ | 13 (8.0) | 9 (7.9) | <0.0001 |
| SLE activity score, mean (SD) | 4.4 (2.8) | 3.0 (2.8) | <0.0001 |
| Hospitalization in the past year, % | 25 | 24 | NS |
| General Health Status* | |||
| PCS-12, mean (SD) | 37 (10.7) | 44 (9.0) | <0.0001 |
| Mortality | |||
| No of deaths, (%) | 63 (7) | 9 (9) | NS |
| Age of death, mean (range), y | 52 (23-100) | 33 (19-49) | <0.0001 |
SLE= Systemic Lupus Erythematosus, ACR= American College of Rheumatology, CESD= Center for Epidemiologic Studies Depression Scale, SLAQ= Systemic Lupus Activity Questionnaire, PCS-12= Short Form-12 Physical Component Score
*
Data from most recent interview
§
Data from baseline interview
†
Includes history of heart disease or heart attack
‡
Missing data for 62 adult-onset and 8 childhood-onset subjects with only baseline data