Fig. 6.
Vaginal HSV-2 DNA copy number on day 1 (a), day 3 (b) and day 5 (c) following HSV-2 challenge. BALB/c mice (10 per group) were vaccinated three times intramuscularly with 100 µg FL gD2 pDNA (□, PBS FL; ▪, Vaxfectin FL). At day 14 after the last vaccination, mice were inoculated vaginally with 50× LD50 (left graphs) or 500× LD50 (right graphs) of HSV-2. Vaginal swabs were collected and viral genomes were measured by qPCR for HSV-2 DNA. Each symbol represents an individual animal. The mean value for each group is shown by a black horizontal line. Values below the lower limit of detection are listed as zero.