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. 2012 Jun;93(Pt 6):1151–1172. doi: 10.1099/vir.0.041186-0

Table 1. miRNAs and siRNAs and their proposed regulation in HIV-1.

miRNA name Proposed function Reference(s)
miR-17/92 cluster (miR-17-5p and miR-20a) Indirectly affects HIV-1 replication by targeting cellular proteins like histone acetyltransferase (HAT) Tat cofactor PCAF Triboulet et al. (2007)
miR-N367 Suppresses Nef expression Omoto & Fujii (2005); Omoto et al. (2004)
hsa-miR-29a Interferes with Nef protein expression and HIV-1 replication; directs HIV-1 transcripts to P bodies Ahluwalia et al. (2008); Nathans et al. (2009)
miR-28, miR-125b, miR-150, miR-223, miR-382 Target sequences in the 3′ end of HIV-1 RNA Huang et al. (2007)
miR-TAR-5p, miR-TAR-3p Chromatin remodelling of the HIV-1 LTR; inhibits apoptosis by downregulating ERCC1 and IER3 Klase et al. (2007, 2009); Ouellet et al. (2009)
vsiRNA1 Rescues Env mRNA expression Bennasser et al. (2005)
miR-122, miR-370, miR-373, miR-297 Unclear in HIV-1 infection but were shown to be upregulated during HIV-1 infection of Jurkat T-cells Triboulet et al. (2007)
miR-29c, miR-26a, miR-21 Unclear, shown to be downregulated in HIV-1 patient samples Houzet et al. (2008)
miR-146a Targets CCL8/MCP-2 in HIV-1-infected microglia for maintenance of HIV-mediated chronic inflammation of the brain Rom et al. (2010)
miR-34a Targets transcription factor CREB (levels deregulated by Vpr resulting in neuronal dysfunction) Mukerjee et al. (2011)
Predicted in silico
hsa-miR-29a and -29b Targets Nef gene Hariharan et al. (2005)
hsa-miR-149 Targets Vpr gene Hariharan et al. (2005)
hsa-miR-378 Targets Env Hariharan et al. (2005)
hsa-miR-324-5p Targets Vif gene Hariharan et al. (2005)