miR-17/92 cluster (miR-17-5p and miR-20a) |
Indirectly affects HIV-1 replication by targeting cellular proteins like histone acetyltransferase (HAT) Tat cofactor PCAF |
Triboulet et al. (2007) |
miR-N367 |
Suppresses Nef expression |
Omoto & Fujii (2005); Omoto et al. (2004) |
hsa-miR-29a |
Interferes with Nef protein expression and HIV-1 replication; directs HIV-1 transcripts to P bodies |
Ahluwalia et al. (2008); Nathans et al. (2009) |
miR-28, miR-125b, miR-150, miR-223, miR-382 |
Target sequences in the 3′ end of HIV-1 RNA |
Huang et al. (2007) |
miR-TAR-5p, miR-TAR-3p |
Chromatin remodelling of the HIV-1 LTR; inhibits apoptosis by downregulating ERCC1 and IER3
|
Klase et al. (2007, 2009); Ouellet et al. (2009) |
vsiRNA1 |
Rescues Env mRNA expression |
Bennasser et al. (2005) |
miR-122, miR-370, miR-373, miR-297 |
Unclear in HIV-1 infection but were shown to be upregulated during HIV-1 infection of Jurkat T-cells |
Triboulet et al. (2007) |
miR-29c, miR-26a, miR-21 |
Unclear, shown to be downregulated in HIV-1 patient samples |
Houzet et al. (2008) |
miR-146a |
Targets CCL8/MCP-2 in HIV-1-infected microglia for maintenance of HIV-mediated chronic inflammation of the brain |
Rom et al. (2010) |
miR-34a |
Targets transcription factor CREB (levels deregulated by Vpr resulting in neuronal dysfunction) |
Mukerjee et al. (2011) |
Predicted in silico |
|
|
hsa-miR-29a and -29b |
Targets Nef gene |
Hariharan et al. (2005) |
hsa-miR-149 |
Targets Vpr gene |
Hariharan et al. (2005) |
hsa-miR-378 |
Targets Env
|
Hariharan et al. (2005) |
hsa-miR-324-5p |
Targets Vif gene |
Hariharan et al. (2005) |