Table 2.
Multivariate analysis of predictors for (A) overall survival (6 months) and (B) initial response (complete or partial) for MSC treatment
| A. Cox multivariate analysis of 6 months OS after 1st MSC treatment | |||
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| Predictor | HR | 95.0% CI for HR | Sig. |
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| Age in years | 1.059 | 1.023-1.097 | 0.001 |
| Skin GVHD grade (0-4) | 0.940 | 0.618-1.428 | 0.770 |
| Gut GVHD grade (0-4) | 0.950 | 0.360-2.504 | 0.917 |
| Liver GVHD grade (0-4) | 0.794 | 0.537-1.174 | 0.248 |
| Overall GVHD grade (0-4) | 1.341 | 0.182-9.894 | 0.774 |
| Time to the 1st MSC treatment after HSCT | 1.000 | 0.987-1.013 | 0.993 |
| Time to the 1st MSC after GVHD onset | 0.953 | 0.905-1.004 | 0.071 |
| Clinical response for MSC treatment | 29.374 | 7.837-110.100 | 0.000 |
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| B. Response analysis by binary logistic regression | |||
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| Predictor | OR | 95.0% CI for OR | Sig. |
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| Age in years | 1.009 | 0.951-1.071 | 0.767 |
| Time to the 1st MSC treatment after BMT | 0.914 | 0.797-1.047 | 0.195 |
| Skin GVHD grade (0-4) | 0.694 | 0.208-2.314 | 0.552 |
| Gut GVHD grade (0-4) | 0.513 | 0.103-2.565 | 0.417 |
| Liver GVHD grade (0-4) | 2.546 | 1.132-5.728 | 0.024 |
| Number of MSC per kg cells (all treatments) | 0.868 | 0.301-2.502 | 0.794 |
| 1st MSC dose after GvHD onset | 1.060 | 0.925-1.213 | 0.402 |
Abbreviations: HR - Hazard Ratio; OR - Odds Ratio; CI - confidential Interval; in bold - significant ones.