Table 3.
Summary of mitral/aortic valve findings seen on cardiac ultrasounds in infants <1 year of age with severe untreated MPS I
| Number affected | Doppler velocity mean (range) | |
|---|---|---|
| Mitral valve | ||
| Incidence thickened mitral valve | 13/13 (100 %) | - |
| Incidence of mitral regurgitation None Trace Mild or moderate |
4/13 (31 %) 6/13 (46 %) 3/13 (23 %) |
- |
| Mitral valve stenosis E-wave flow signal (m/s) |
0/13 (0 %) 13 |
0.85 ± 0.16 (0.6–1.1) |
| Aortic valve | ||
| Incidence thickened aortic valve | 10/13 (77 %) | - |
| Incidence aortic regurgitation None Trace |
8/13 (62 %) 5/13 (38 %) |
- |
| Aortic valve stenosis Peak systolic flow signal (m/s) |
0/11 (0 %) 11 |
0.84 ± 0.22 (0.49–1.14) |