Table 1.

PBRN challenges

Challenge	Potential solutions
Managing relationships  with PBRN members	Established communication infrastructure, budget for  communications, interactive web site, newsletters, open meetings
Ongoing financial support	Institutional support; study budgets to include ongoing management  and infrastructure support
PBRN productivity	Include team members who write for publication; review potential  projects for committed authors and scientific interest beyond the  PBRN members
Responsible conduct  of research issues	Budget money and time to account for IRB complexities and the  training of PBRN members in the responsible conduct of research
Recruitment and  generalizability	Incentivize participation; don’t restrict recruitment to atypical  members
Measurement validity	Recognize potential for measurement problems, pilot measurement  protocols, conduct mini-validity studies