The putative complex is exceptionally stable.
A. Western blot of nuclear and cytosolic fractions from rat forebrain, probed with anti-pERK1/2 antibody. Samples in SDS-PAGE sample buffer were boiled for 5, 15, or 30 minutes.
B. Western blot of nuclear and cytosolic fractions from rat forebrain, probed with anti-ERK1/2 antibody. Samples in SDS-PAGE sample buffer were boiled for 5, 15, or 30 minutes. Similar findings were observed when samples were boiled with 6 M GdnHCl, 9 M urea, or 10% SDS.