Figure 6.
SKOV3.Luc cells (1.0×107vp) were injected IP into the abdomen of female BALB/c nude mice. Mice were divided into groups (n=15) and each group was treated with CRAds (1.0×109 vp) or PBS on Days 0, 7, and 14. Abdominal tumors increased in size in mice from Day 0 to Day 35 as determined by detection of photons following IP injection of luciferase substrate (A). Asterisk (*) indicates that all mice from PBS group had died by day 35 (with the exception of one outlier). Quantitative analysis of photons emitted by abdominal tumors indicated an increased rate of growth of PBS-injected mice as compared with CRAd-injected mice (B). Asterisk (*) indicates that all mice from PBS group were dead by day 35 so data could not be generated for this group. Mice injected with Δ24 (P=0.0015), Δ24IXRGD (P=0.032), or Δ24FiberRGD (P=0.007) showed a significant increase in survival as compared to PBS-treated mice. Δ24DoubleRGD showed a non-significant (P=0.11) increase in survival versus PBS-treated mice. Survival of mice treated with each of the CRAds was similar (C).