Table 2.
Associations Between FTO rs8050136 (Per-Allele Change) and Total Energy Intake and Percentages of Calories Derived From Carbohydrate, Protein, and Fat Among 36,973 Adults, PAGE Study, 2008–2012
| Study Population |
P-heterogeneitya | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MEC (1993–1996) (n = 19,529) |
CALiCo: ARIC (1987–1989) (n = 11,114) |
EAGLE-NHANES III (1991–1994) (n = 6,330) |
Meta-Analysis (n = 36,973) |
||||||||||
| βb | SE | P Value | β | SE | P Value | β | SE | P Value | β | SE | P Value | ||
| Total energy intake, kcal/day | −0.0006 | 0.0048 | 0.90 | −0.0103 | 0.0049 | 0.03 | 0.0125 | 0.0084 | 0.14 | −0.0028 | 0.0032 | 0.38 | 0.05 |
| % of calories from carbohydrate | −0.2624 | 0.0940 | 5 × 10−3 | −0.3716 | 0.1259 | 3 × 10−3 | −0.1088 | 0.2104 | 0.61 | −0.2796 | 0.0709 | 8 × 10−5 | 0.54 |
| % of calories from proteinc | 0.0730 | 0.0307 | 0.02 | 0.2511 | 0.0548 | 5 × 10−6 | −0.0411 | 0.0881 | 0.64 | 0.1040 | 0.0735 | 0.16 | 0.004 |
| % of calories from fat | 0.2206 | 0.0750 | 3 × 10−3 | 0.2071 | 0.0909 | 0.02 | 0.3064 | 0.1718 | 0.07 | 0.2244 | 0.0548 | 4 × 10−5 | 0.88 |
| % of calories from alcohol | 0.0004 | 0.0102 | 0.97 | −0.0006 | 0.0130 | 0.96 | −0.0254 | 0.0177 | 0.15 | −0.0043 | 0.0073 | 0.55 | 0.05 |
| % of calories from specific types of fat | |||||||||||||
| Polyunsaturated fat | 0.0562 | 0.0211 | 8 × 10−3 | 0.0147 | 0.0197 | 0.45 | 0.1444 | 0.0659 | 0.03 | 0.0391 | 0.0141 | 5 × 10−3 | 0.09 |
| Monounsaturated fat | 0.0724 | 0.0302 | 0.02 | 0.0951 | 0.0400 | 0.02 | 0.1182 | 0.0739 | 0.11 | 0.0843 | 0.0229 | 2 × 10−4 | 0.80 |
| Saturated fat | 0.0725 | 0.0267 | 7 × 10−3 | 0.0632 | 0.0404 | 0.12 | 0.0349 | 0.0726 | 0.63 | 0.0667 | 0.0213 | 2 × 10−3 | 0.88 |
Abbreviations: ARIC, Atherosclerosis Risk in Communities; CALiCo, Causal Variants Across the Life Course; EAGLE, Epidemiologic Architecture for Genes Linked to Environment; MEC, Multiethnic Cohort; NHANES III, Third National Health and Nutrition Examination Survey; PAGE, Population Architecture using Genomics and Epidemiology; SE, standard error.
a Heterogeneity by study.
b Slope from regression of macronutrient intake on FTO rs8050136, using an additive genetic model, adjusted for age at blood draw, sex, and race/ethnicity. This represents the change in the level of the nutrient, such as percentage of energy derived from fat, associated with a change in 1 variant allele.
c Because of heterogeneity by study, the meta-analyzed results from the random-effects model are presented.