Table 2.
Singleton Neonatal Outcomes Associated With Maternal Thyroid Diseases in the Consortium on Safe Labor, 2002–2008
| Neonatal Complications | No Thyroid Disease (n = 216,901) |
Primary Hypothyroidism (n = 3,183) |
Iatrogenic Hypothyroidism (n = 178) |
Hyperthyroidism (n = 417) |
Other or Unspecified Thyroid Disease (n = 2,833) |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | % | aORa | No. | % | aORa | 95% CI | No. | % | aORa | 95% CI | No. | % | aORa | 95% CI | No. | % | aORa | 95% CI | |
| Perinatal mortality | 1,421 | 0.7 | 1.00 | 16 | 0.5 | 0.93 | 0.57, 1.53 | 1 | 0.6 | 1.05 | 0.15, 7.35 | 5 | 1.2 | 1.82 | 0.74, 4.44 | 19 | 0.7 | 1.15 | 0.72, 1.82 |
| Neonatal resuscitation | 49,508 | 22.8 | 1.00 | 894 | 28.1 | 1.05 | 0.95, 1.15 | 65 | 36.5 | 1.43 | 0.98, 2.09 | 113 | 27.1 | 1.41 | 1.10, 1.80 | 885 | 31.2 | 0.98 | 0.89, 1.08 |
| Level of resuscitation CPAP or higherb | 3,647 | 1.7 | 1.00 | 74 | 2.3 | 1.07 | 0.84, 1.36 | 6 | 3.4 | 1.56 | 0.66, 3.68 | 12 | 2.9 | 1.72 | 0.95, 3.11 | 46 | 1.6 | 1.02 | 0.75, 1.37 |
| Neonate admitted to NICUc | 26,317 | 12.1 | 1.00 | 434 | 13.6 | 1.22 | 1.10, 1.35 | 34 | 19.1 | 1.71 | 1.16, 2.51 | 87 | 20.9 | 1.66 | 1.30, 2.12 | 373 | 13.2 | 1.13 | 1.01, 1.26 |
| Respiratory distress syndrome | 7,058 | 3.3 | 1.00 | 128 | 4.0 | 1.29 | 1.08, 1.55 | 11 | 6.2 | 1.82 | 0.97, 3.41 | 28 | 6.7 | 1.77 | 1.20, 2.61 | 110 | 3.9 | 1.18 | 0.98, 1.44 |
| Apnead | 4,532 | 2.3 | 1.00 | 91 | 2.9 | 1.34 | 1.08, 1.66 | 7 | 3.9 | 1.70 | 0.77, 3.75 | 23 | 5.6 | 2.01 | 1.31, 3.07 | 66 | 2.7 | 1.41 | 1.10, 1.81 |
| Transient tachypnea | 7,743 | 3.6 | 1.00 | 146 | 4.6 | 1.29 | 1.09, 1.53 | 9 | 5.1 | 1.41 | 0.71, 2.77 | 27 | 6.5 | 1.58 | 1.07, 2.35 | 88 | 3.1 | 0.97 | 0.78, 1.20 |
| Sepsis | 6,017 | 2.8 | 1.00 | 99 | 3.1 | 1.42 | 1.16, 1.74 | 12 | 6.7 | 2.86 | 1.58, 5.17 | 22 | 5.3 | 1.61 | 1.03, 2.49 | 79 | 2.8 | 1.25 | 0.99, 1.57 |
| Anemia | 4,058 | 1.9 | 1.00 | 68 | 2.1 | 1.28 | 1.00, 1.64 | 9 | 5.1 | 2.66 | 1.32, 5.39 | 16 | 3.8 | 1.55 | 0.94, 2.57 | 56 | 2.0 | 1.18 | 0.90, 1.55 |
Abbreviations: aOR, adjusted odds ratio; CI, confidence interval; CPAP, continuous positive airway pressure; NICU, neonatal intensive care unit.
a aORs are obtained from multivariate logistic regression with generalized estimating equations to account for correlated data. All results are adjusted for site, maternal age, insurance status, parity, smoking, race/ethnicity, and other chronic diseases.
b Level of resuscitation is missing for 498 infants with documented need of resuscitation.
c Once the infant was admitted, the median length of NICU stay (minimum − maximum) was 7.0 days (0–483 days) if the mother did not have thyroid disease; 7.7 days (0–189 days) if the mother had primary hypothyroidism; 8.0 days (1–99 days) if the mother had iatrogenic hypothyroidism; 10.0 days (0–131 days) if the mother had hyperthyroidism; and 7.0 days (0–175 days) if the mother had other or unspecified thyroid disease. The differences were not statistically significant when comparing the length of NICU stay of infants of mothers with thyroid disease with those of mothers without thyroid disease.
d Apnea information is missing for all observations from 1 study site (n = 20,596).