Table 3. Rescue medication use.
| Indacaterol 150 µg | Tiotropium 18 µg | Salmeterol 50 µg | Placebo | |
|---|---|---|---|---|
| Change from baseline in mean daily number of puffs of rescue medication (LSM ± SE) | ||||
| INHANCE (49) | –1.50±0.130***††† | –1.00±0.130*** | – | –0.40±0.140 |
| INDORSE (50) | –1.20±0.280*** | – | – | –0.10±0.300 |
| INLIGHT-2 (51) | –1.30±0.160*** | – | –1.20±0.160*** | –0.30±0.160 |
| INLIGHT-1 (52) | –1.38±0.118*** | – | – | –0.41±0.122 |
| INTENSITY (54) | –1.40±0.097††† | –0.85±0.097 | – | – |
| Proportion of days on which no rescue medication (%) | ||||
| INHANCE (49) | 56.7***††† | 46.1 | – | 41.8 |
| INDORSE (50) | 56.0* | – | – | 46.0 |
| INLIGHT-2 (51) | 59.7***‡ | – | 54.7*** | 42.2 |
| INLIGHT-1 (52) | 54.6*** | – | – | 41.3 |
| INTENSITY (54) | 46.1†† | 41.4 | – | – |
***P<0.001 vs. placebo, **P<0.01 vs. placebo, *P<0.05 vs. placebo, †††P≤0.001 vs. tiotropium, ††P<0.01 vs. tiotropium, ‡P<0.05 vs. salmeterol. LSM, least squares mean; SE, standard error.