. 2013 Aug 21;33(34):13820–13833. doi: 10.1523/JNEUROSCI.1671-13.2013

Table 2.

RSD increased IL-1β mRNA expression in the CTX-R, BG, HYPO, and HPC independent of genotype

Region: genotype	Controls	RSD
CTX-R:
WT	1.05 ± 0.16	2.76 ± 0.18^*
CCR2^KO	1.18 ± 0.19	1.68 ± 0.29
CX₃CR1^HET	1.47 ± 0.21	2.18 ± 0.38^#
CX₃CR1^KO	1.63 ± 0.27	2.00 ± 0.24
BG:
WT	1.01 ± 0.09	2.98 ± 0.84^*
CCR2^KO	1.25 ± 0.24	2.52 ± 0.42^*
CX₃CR1^HET	1.08 ± 0.06	3.01 ± 0.52^*
CX₃CR1^KO	1.22 ± 0.04	2.82 ± 0.56^*
HYPO:
WT	1.04 ± 0.16	2.74 ± 0.47^*
CCR2^KO	1.40 ± 0.12	2.44 ± 0.38^#
CX₃CR1^HET	1.16 ± 0.21	2.16 ± 0.32^*
CX₃CR1^KO	1.25 ± 0.21	2.69 ± 0.54^*
HPC:
WT	1.01 ± 0.07	3.46 ± 0.97^*
CCR2^KO	1.15 ± 0.02	2.39 ± 0.33^*
CX₃CR1^HET	1.65 ± 0.41	3.20 ± 0.66^*
CX₃CR1^KO	1.27 ± 0.18	3.00 ± 0.54^*

Male WT, CCR2^KO, CX₃CR1^HET, and CX₃CR1^KO C57BL/6 mice were subjected to six cycles of social defeat (RSD) or left undisturbed as controls. Brains were removed, dissected, and frozen in liquid nitrogen 14 h after the final cycle of RSD. IL-1β mRNA levels were determined in the CTX-R, HYPO, BG, and HPC (n = 4–6, 4 independent experiments). Values represent average fold change compared to WT control. Means with asterisk (*) are significantly different from controls (p < 0.05) and means with number sign (#) are different from controls (p < 0.10).