Table 1.
Kinetic parameters of NMDA receptor-mediated EPSC deactivation
Condition | τfast (ms) | Ifast | τslow (ms) | Islow | τw (ms) | Po* | Q60 (ms) |
---|---|---|---|---|---|---|---|
WT | 43.7 ± 11.2 | 0.803 ± 0.105 | 343.8 ± 99.3 | 0.198 ± 0.094 | 107.6 ± 61.3 | 0.35 ± 0.08 | 24.2 ± 7.1 |
N2B KO (A-type) | 19.8 ± 2.1 | 0.993 ± 0.085 | 119.8 ± 69.7 | 0.036 ± 0.017 | 22.7 ± 2.2 | 0.52 ± 0.06 | 14.0 ± 1.8 |
N2A KO (B-type) | 142.7 ± 31.0 | 0.369 ± 0.088 | 596.9 ± 137.8 | 0.606 ± 0.101 | 314.9 ± 73.3 | 0.24 ± 0.08 | 109.7 ± 25.2 |
AB-type | 35.3 ± 3.3 | 0.841 ± 0.039 | 322.8 ± 71.9 | 0.143 ± 0.033 | 78.7 ± 12.6 | 0.28 ± 0.07 | 58.7 ± 26.8 |
AB-type + ifenprodil | 41.5 ± 4.38 | 0.811 ± 0.069 | 370.5 ± 170 | 0.118 ± 0.048 | 78.3 ± 16.4 | ND | ND |
AB-type + zinc | 44.9 ± 7.66 | 0.693 ± 0.044 | 317.1 ± 71.1 | 0.264 ± 0.038 | 118.9 ± 22.1 | ND | ND |
AB-type, model | 41.6 ± 0.3 | 0.869 ± 0.039 | 164.3 ± 78.5 | 0.131 ± 0.039 | ND | ND | ND |
Data are shown as means ± SD. ND indicates not determined.