Table 4.
Cox proportional hazard relating coexistence of a) AD-HS, b) AD, and c) HS to overall survival compared to BC patients without these comorbidities
| a) BC patients with coexisting AD or HS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All patients. N=1508, N=1363 and N=1363. | ||||||||||
| HR | 95% CI for HR | p-value | ||||||||
| AD-HS, adjusted for: | N | Lower | Upper | |||||||
| Age at diagnosis | 194 | 0.88 | 0.71 | 1.10 | 0.25 | |||||
| Age at diagnosis, TNM-stage | 185 | 0.91 | 0.72 | 1.14 | 0.409 | |||||
| Age at diagnosis, TNM-stage, Screening | 185 | 0.94 | 0.75 | 1.18 | 0.579 | |||||
| Patients younger than 65 years at diagnosis of BC. N=1021 | Patients younger than 50 years at diagnosis of BC. N=473 | |||||||||
| N | HR | 95% CI for HR | p-value | N | HR | 95% CI for HR | p-value | |||
| AD-HS, adjusted for: | Lower | Upper | Lower | Upper | ||||||
| Age at diagnosis, TNM-stage | 130 | 0.94 | 0.75 | 1.18 | 0.579 | 56 | 0.74 | 0.48 | 1.16 | 0.186 |
| b) BC patients with coexisting AD | ||||||||||
| All patients. N=1580 and N=1433 | ||||||||||
| N | HR | 95% CI for HR | p-value | |||||||
| AD adjusted for: | Lower | Upper | ||||||||
| Age at diagnosis | 122 | 0.90 | 0.48 | 1.16 | 0.460 | |||||
| Age at diagnosis, TNM-stage | 115 | 0.90 | 0.69 | 1.20 | 0.480 | |||||
| Patients younger than 65 years at diagnosis of BC. N=1071 | Patients younger than 50 years at diagnosis of BC. N=500 | |||||||||
| N | HR | 95% CI for HR | p-value | N | HR | 95% CI for HR | p-value | |||
| AD adjusted for: | Lower | Upper | Lower | Upper | ||||||
| Age at diagnosis, TNM-stage | 80 | 0.95 | 0.66 | 1.36 | 0.773 | 29 | 0.81 | 0.45 | 1.45 | 0.472 |
| c) BC patients with coexisting HS | ||||||||||
| All patients included. N= 1632 and N=1363 | ||||||||||
| N | HR | 95% CI for HR | p-value | |||||||
| HS adjusted for: | Lower | Upper | ||||||||
| Age at diagnosis | 72 | 0.85 | 0.60 | 1.23 | 0.388 | |||||
| Age at diagnosis, TNM-stage | 70 | 0.93 | 0.64 | 1.34 | 0.691 | |||||
| Patients younger than 65 years at diagnosis of BC. N=1101 | Patients younger than 50 years at diagnosis of BC. N=502 | |||||||||
| N | HR | 95% CI for HR | p-value | N | HR | 95% CI for HR | p-value | |||
| HS adjusted for: | Lower | Upper | Lower | Upper | ||||||
| Age at diagnosis, TNM-stage | 50 | 0.86 | 0.54 | 1.37 | 0.524 | 27 | 0.69 | 0.36 | 1.33 | 0.269 |
The HR shown is for a) AD-HS combined, b) AD, or c) HS adjusted for the variables in the left column.
All analyses were performed using all patients, with an age cutoff at less than 65 years old, and an age cutoff at less than 50 years old for each group respectively.