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. Author manuscript; available in PMC: 2013 Aug 28.
Published in final edited form as: Pain. 2010 Feb 19;149(1):135–142. doi: 10.1016/j.pain.2010.01.024

Fig. 5.

Fig. 5

(A) Intravenous injection of 1 mg/kg of ch14.18 in PVG (C+) rats results in a prolonged decrease in mechanical withdrawal thresholds that were comparable to that seen in Sprauge–Dawley rats. In marked contrast, the same injection in PVG (C−) rats resulted in much less severe allodynia that varied significantly from both the Sprague–Dawley and the PVG (C+) rats injected with ch14.18. Injection of hu14.18K322A into C− rats resulted in a strong tendency towards even less allodynia. (B) Areas over the curve indicate the sum of activity over the first 2 h post-injection and the period from 2.5–4.5 h post-injection. C− rats injected with either dose of hu were no different than saline injected animals. *p 6 0.001–0.02 compared to C+ch1; #p 6 0.01 compared to C−ch1.