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. Author manuscript; available in PMC: 2013 Oct 11.
Published in final edited form as: N Engl J Med. 2013 Mar 27;368(15):1398–1407. doi: 10.1056/NEJMoa1211592

Table 1.

Associations of 17q21 Single-Nucleotide Polymorphisms (SNPs) with Asthma, Allergic Sensitization, and Viral Wheezing Illness Phenotypes in the Childhood Origins of Asthma (COAST) Cohort.*

SNP Gene Location Minor
Allele
Minor-Allele
Frequency
P Value
Asthma Allergic
Sensitization
HRV
Wheezing
Illness
No. of HRV
Wheezing
Illnesses
RSV
Wheezing
Illness
No. of RSV
Wheezing
Illnesses
rs9303277 IKZF3 Intron C 0.488 0.03 0.86 0.01 <0.001 0.25 0.51
rs11557467 ZPBP2 Intron T 0.498 0.05 0.98 0.02 <0.001 0.30 0.63
rs12936231 ZPBP2 Exon C 0.493 0.07 0.95 0.02 <0.001 0.22 0.57
rs2290400 GSDMB Intron A§ 0.500 0.08 0.90 0.02 <0.001 0.17 0.47
rs7216389 GSDMB Intron T§ 0.500 0.04 0.90 0.01 <0.001 0.22 0.54
*

HRV denotes human rhinovirus, and RSV respiratory syncytial virus.

Allergic sensitization was assessed with the use of an in vitro IgE test. The results were similar when allergic sensitization was assessed with the use of a skin-prick test (all P>0.50).

This was the minor allele in the COAST cohort.

§

The minor allele in Centre d’Etude du Polymorphisme Humain from Utah (CEU) HapMap samples is shown for this SNP.

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