Table 1.
Associations of 17q21 Single-Nucleotide Polymorphisms (SNPs) with Asthma, Allergic Sensitization, and Viral Wheezing Illness Phenotypes in the Childhood Origins of Asthma (COAST) Cohort.*
SNP | Gene | Location | Minor Allele |
Minor-Allele Frequency |
P Value | |||||
---|---|---|---|---|---|---|---|---|---|---|
Asthma | Allergic Sensitization† |
HRV Wheezing Illness |
No. of HRV Wheezing Illnesses |
RSV Wheezing Illness |
No. of RSV Wheezing Illnesses |
|||||
rs9303277 | IKZF3 | Intron | C‡ | 0.488 | 0.03 | 0.86 | 0.01 | <0.001 | 0.25 | 0.51 |
rs11557467 | ZPBP2 | Intron | T‡ | 0.498 | 0.05 | 0.98 | 0.02 | <0.001 | 0.30 | 0.63 |
rs12936231 | ZPBP2 | Exon | C‡ | 0.493 | 0.07 | 0.95 | 0.02 | <0.001 | 0.22 | 0.57 |
rs2290400 | GSDMB | Intron | A§ | 0.500 | 0.08 | 0.90 | 0.02 | <0.001 | 0.17 | 0.47 |
rs7216389 | GSDMB | Intron | T§ | 0.500 | 0.04 | 0.90 | 0.01 | <0.001 | 0.22 | 0.54 |
HRV denotes human rhinovirus, and RSV respiratory syncytial virus.
Allergic sensitization was assessed with the use of an in vitro IgE test. The results were similar when allergic sensitization was assessed with the use of a skin-prick test (all P>0.50).
This was the minor allele in the COAST cohort.
The minor allele in Centre d’Etude du Polymorphisme Humain from Utah (CEU) HapMap samples is shown for this SNP.