Table 3.
NMR spectroscopic data of thailandepsin F (6) in CDCl3
| position | δC, type | δH (J in Hz) | HMBC | |
|---|---|---|---|---|
| Nleu | 1 | 170.8, C═O | 2, 2′, NH, NH′ | |
| 2 | 56.7, CH | 4.15, m | 2′″, NH | |
| 3 | 30.4, CH2 | 1.90, m | 2, 4, 5, NH | |
| 1.72, m | ||||
| 4 | 28.3, CH2 | 1.40, m | 2, 3, 5 | |
| 5 | 22.2, CH2 | 1.43, m | 3, 4, 6 | |
| 6 | 13.9, CH3 | 0.93, m | 4, 5 | |
| NH | 6.26, d (3.1) | |||
| Cys | 1′ | 168.8, C═O | 2′, 3′, NH″ | |
| 2′ | 55.0, CH | 4.83, m (8.6, 4.0) | NH′ | |
| 3′ | 40.4, CH2 | 3.29, m | ||
| 3.15, m | ||||
| NH′ | 6.81, d (8.9) | |||
| Ah(6)hpa | 1″ | 171.4, C═O | 2″, 3″ | |
| 2″ | 38.8, CH2 | 2.73, m | 3″, 4″ | |
| 3″ | 70.7, CH | 4.36, m | 2″, 4″, 5″, NH″ | |
| 4″ | 56.0, CH | 3.12, m | 2″, 3″, 5″, NH″ | |
| 5″ | 38.7, CH2 | 2.08, m | 3″, 4″ | |
| 1.46, m | ||||
| 6″ | 25.1, CH | 1.63, m | 5″, 7″, 8″ | |
| 7″ | 21.0, CH3 | 0.93, m | 5″, 6″ | |
| 8″ | 23.4, CH3 | 0.91, m | 5″, 6″ | |
| NH″ | 7.52, d (7.0) | |||
| OH″ | ||||
| acyl | 1′″ | 171.1, C═O | 2′″, NH | |
| 2′″ | 40.9, CH2 | 3.37, m | ||
| 2.70, m | ||||
| 3′″ | 70.6, CH | 5.49, br s | 4′″ | |
| 4′″ | 128.8, CH | 5.73, d (15.4) | 2′″, 3′″, 6′″ | |
| 5′″ | 133.2, CH | 6.40, m (13.5) | ||
| 6′″ | 32.8, CH2 | 2.72, m | 4′″ | |
| 2.45, m | ||||
| 7′″ | 40.9, CH2 | 3.38, m | ||
| 2.73, m |
a
Ah(6)hp: 4-amino-3-hydroxy-6-methylheptanoic acid.