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Spleen weight as a percent of body weight for each genotype of Ednrb mice. Seven Ednrb mice of each genotype Ednrb+/+, +/−, and −/− at post-natal day 25 had body weight and wet weight of the spleen measured. The mean Ednrb−/− spleen weight was significantly reduced compared with Ednrb+/+ and +/− (P < 0.0001); there was no difference between the Ednrb+/+ and +/− spleen weight. Groups were compared using student’s t test, data were expressed as mean ± SD. ***P < 0.001
