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. Author manuscript; available in PMC: 2013 Aug 28.
Published in final edited form as: Pediatr Surg Int. 2011 Feb;27(2):145–150. doi: 10.1007/s00383-010-2787-y

Fig. 3.

Fig. 3

Histology and immunofluorescence staining of Ednrb+/+ and Ednrb−/− spleens. Ednrb+/+ a, b, c (upper panel) and Ednrb−/− d, e, f (lower panel). H and E staining (a, b and d, e); a and d (40×), b and e (100×) show significantly reduced white pulp (WP) with lymphopenia, fewer primary follicles and poorly defined marginal zone (arrow) in the Ednrb−/− (d and e) compared to Ednrb+/+ (a and b). Immunofluorescence staining for CD45R and CD3 of Ednrb+/+ (c) and Ednrb−/− mice (f). CD45R labels B cells red; CD3 labels T cells green