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. 2013 Aug 28;8(8):e74340. doi: 10.1371/journal.pone.0074340

Figure 7. Gck knockdown impairs glucose tolerance in both wild-type and LTKO mice.

Figure 7

(A) Gck protein was analyzed in the livers of 3-month-old control and LTKO mice by Western blots. (B) Gck knockdown was assessed by Western blots in liver lysates from control and LTKO mice injected with shGck or shGFP adenoviruses. (C, D) Glucose tolerance tests and insulin tolerance tests in 6-month-old male control and LTKO mice injected with shGck or shGFP adenoviruses (n=5-6), respectively. Data represent mean ± SEM. *, P<0.05 between LTKO-shGFP and LTKO-shGck groups; #, P<0.05 between loxp-shGFP and loxp-shGck groups.