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. 2013 Aug 28;8(8):e73502. doi: 10.1371/journal.pone.0073502

Figure 8. Vasodilator capacity to decrease maximal hypoxic mPAP and AUCSaO2.

Figure 8

Vasodilator capacity to decrease maximal hypoxic mPAP (positive treatment effect) and AUCSaO2 (unwanted desaturation effect) based on (A) pooled effects at all dose levels tested (N = 6, four doses per group) and (B) at each drug's maximal effective dose (i.e., cumulative dose) (mean ± SEM, N = 6, doses as indicated). *P<0.05 vs vehicle. AUCSaO2, area under the SaO2 curve; SaO2, arterial oxygen saturation of hemoglobin; mPAP, mean pulmonary artery pressure; SEM, standard error of the mean.