Figure 3. Inhibition of PKCζ expression significantly reduces orthotopic pancreatic tumor size.

A) Representative bioluminescent imaging of mice with orthotopic Panc-1 NT and PKCζ RNAi pancreatic tumors. B) Representative H&E stained sections of orthotopic Panc-1 NT and PKCζ RNAi pancreatic tumors. The remaining normal mouse pancreas is circled in blue. C) Inhibition of PKCζ significantly decreased the pancreas and orthotopic tumor weight; n = 16; *p<0.001.