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. 2013 Aug 28;8(8):e72122. doi: 10.1371/journal.pone.0072122

Figure 2. Genome wide association and linkage analyses.

Figure 2

A) A Manhattan plot of genome-wide case-control association analysis performed using 6 cases and 14 controls indicate the most highly associated region in CFA2. B) The PRA associated region on chromosome 2 spans from 61.4 Mb to 63.3 Mb based on association, linkage and joint analyses. C) Genotypes at the PRA associated region on CFA2. All cases share a 1.9 Mb homozygous block, and within this block SNPs BICF2S23238410, BICF2P309315 and BICF2P75954 show complete recessive segregation with the disease. D) Chromatograms of the c.2685delA (arrow), c.2687_2688insTAGCTA (shadowed) mutations in CNGB1 gene in an affected (2) and normal (1) dog. The CNGB1 gene is located between the two segregating SNPs (BICF2P309315, BICF2P75954).