Figure 2. Schematic representation of the process of substantiation of suspected drug-induced adverse events via proteins (A) and via pathways (B).

(From Bauer-Mehren A, van Mulligen EM, Avillach P, Carrascosa Mdel C, Garcia-Serna R, et al. (2012) Automatic filtering and substantiation of drug safety signals. PLoS Comput Biol 8: e1002457. Reproduced with permission from the authors).