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. Author manuscript; available in PMC: 2013 Aug 28.
Published in final edited form as: Neuron. 2008 Apr 10;58(1):78–88. doi: 10.1016/j.neuron.2008.01.019

Figure 4. CK1εtau has a global impact on circadian pacemaking, accelerating molecular circadian oscillators in SCN, peripheral tissues and primary fibroblasts.

Figure 4

(A) Representative PER2::LUC bioluminescence oscillations in WT (red), heterozygote (green) and homozygote (blue) organotypic SCN slices.

(B) The periodicity of tissues from WT, heterozygote and homozygote tau PER2::LUC mice (mean±SEM; WT, n=4-6; heterozygotes, n=10-11; homozygote, n=5-6).

(C) CCD recordings of SCN PER2::LUC expression at the single cell level for WT and homozygote SCN slices (20 per slice; n=3 slices for each genotype).

(D) Representative traces of PER2::LUC expression in primary fibroblast cultures of WT (red) and tau mutant (blue) mice.

(E) Waveform alignments by nadir or peak for PER2::LUC rhythms from WT (red) and homozygote (blue) organotypic SCN slices. Data were normalised and then plotted as mean±SEM (n=6 per genotype). Note selective reduction in peak to nadir interval regardless of alignment.