Figure 3. Expression of aging markers in the lacrimal glands of aged and cGVHD model mice.

Immunohistochemistry for other aging markers in lacrimal glands. Representative lacrimal gland sections immunostained for p16 (A–C) or p38 (D–F). In the aged (B, E) and cGVHD mice (C, F), some mononuclear cells around periductal vessels (arrowheads) or some endothelial cells of blood vessels (arrows) are positive for p16 or p38 whereas few positive cells are found in the young mice (A, D). D; duct, V; Blood vessels. Original magnification. A–D, F X200, E, X400.