. 2010 Dec 23;3(1):17–42. doi: 10.3390/cancers3010017

Table 1.

Plasma pharmacokinetics and tumor accumulation of polymer-paclitaxel conjugates and paclitaxel in mouse models.

Mice	bearing	Treatment	Dose (mg/kg)	AUC (μg·h/g tissue)		Ref.
Mice	bearing	Treatment	Dose (mg/kg)	plasma	tumor	Ref.
Female C3Hf/Kam	Murine ovarian Oca-1 carcinoma	PG-PTX	20	184.1	1097.3	[23]
Female C3Hf/Kam	Murine ovarian Oca-1 carcinoma	Paclitaxel	20	1.8	211.4	[23]
PG-PZX/Paclitaxel ratio				100.9	5.2
Female nude	Human H460 lung cancer	PGG-PTX	40	3454.4	2496	[21]
Female nude	Human H460 lung cancer	Paclitaxel	40	146.3	322.5	[21]
PG-PTX/Paclitaxel ratio				23.6	7.7