Table 3.
Cancer | Drug | Genexol-PM | Taxol | NK-105 | Taxol | NK-105 | Taxol |
---|---|---|---|---|---|---|---|
IC70 (μg/mL) | IC50 (μM) | IC50 (μM) | |||||
Tumor cell line | (96 h drug exposure) | (48 h drug exposure) | (72 h drug exposure) | ||||
Eesophageal | TE-1 | >1.0 | >1.0 | 0.01 | 0.02 | ||
TE-8 | 0.02 | 0.02 | 0.01 | 0.01 | |||
Lung | PC-14 | 0.01 | 0.01 | 0.01 | 0.01 | ||
PC-14/TXT | 0.15 | 0.09 | 0.08 | 0.06 | |||
H460 | 0.03 | 0.01 | |||||
Breast | MCF-7 | 0.002 | 0.002 | >1.0 | >1.0 | 0.01 | 0.01 |
Stomach | MKN-28 | 0.03 | 0.03 | 0.01 | 0.21 | ||
MKN-45 | 0.02 | 0.07 | 0.01 | 0.02 | |||
Colon | DLD-1 | 0.95 | 0.26 | 0.29 | 0.20 | ||
HT-29 | 0.01 | 0.01 | 0.01 | 0.01 | |||
HCT116 | 0.03 | 0.01 | |||||
Ovarian | MCAS | 0.01 | 0.01 | 0.01 | 0.01 | ||
OVCAR-3 | 0.002 | 0.004 | >1.0 | >1.0 | >1.0 | >1.0 | |
Pancreatic | AsPC-1 | 0.02 | 0.02 | ||||
PAN-9 | 0.03 | 0.02 | |||||
PAN-3 | 0.01 | 0.004 | |||||
Ref. | [25] | [24] |