Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Therapeutic intervention points in the signaling pathways that mediate TRAIL-induced apoptosis. Intracellular pathways that culminate in apoptosis following TRAIL-R1 and -R2 ligation are illustrated. Blue arrows indicate apoptotic signaling pathways. Brown arrows indicate molecular intervention points for therapies that augment TRAIL-induced apoptosis. Red arrows indicate up- or down-regulation of specific molecular targets.
