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. 2011 Mar 3;3(1):994–1013. doi: 10.3390/cancers3010994

Figure 1.

Figure 1.

Dominant-negative effect of mutant p53 on wild-type p53. Pro-apoptotic function of p53 is significantly inhibited by certain p53 mutants which induce malignant transformation through up-regulation of c-myc and TERT.