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. 2011 Mar 7;3(1):1158–1181. doi: 10.3390/cancers3011158

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 2. — HSF1 potential roles in cancer. Schematic model of the role of HSF1 in cancer transformation: HSF1 activity is hijacked by several oncogenes or mutated tumor suppressors (represented by dashed arrows) allowing activation of a set of genes involved in cancer development, i.e., proliferation and anchorage independent growth, tumor maintenance, anti-apoptotic signaling, migration/metastasis, aneuploidy and probably other mechanisms, including non-transcriptional mechanisms related to the chromatin modification and genomic instability. Notably, there is growing evidence about the role of HSF2 and HSF4 in tumorigenesis since they are directly connected to different cancer related genes (FGF, cFos, Proteasome subunits). The double arrow represents the crosstalk existing between HSFs.