Table 1.
HSF main characteristics.
| HSF1 | HSF2 | HSF3 | HSF4 | |
|---|---|---|---|---|
| Species Conservation | Human, Mouse, Chicken | Human, Mouse, Chicken | Chicken, Mouse | Human, Mouse, Chicken |
| Oligomerization | NC: Monomer HS: Trimer |
HS: Dimer-heterotrimers HSF1/HSF2 Differentiation: Dimer-heterotrimers HSF1/HSF2 Development: homotrimers/heterotrimers HSF1/HSF2 |
NC and HS: Dimer | NC and HS: Trimer |
| Target genes in stress responses | Hsp genes (+ non-classical stress genes) | Hsp genes (+ non-classical stress genes) Proteasome subunits | Mainly Hsp genes in chicken Non classical stress genes in mice | Not heat-responsive Repression of hsp genes in ectopic expression experiments |
| Developmental role of HSF | Oogenesis, maternal factor, development and maintenance of germ, ciliated and immune cells | Brain and gametogenesis development | ND | Development and maintenance of sensory organs |
| Adult tissue localization | Ubiquitous | Ubiquitous | Ubiquitous | Tissue specific (heart, brain, skeletal muscle, and pancreas) |
NC: Normal conditions; HS: Heat shock; ND: Not determined.