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. 2011 Mar 15;3(1):1329–1350. doi: 10.3390/cancers3011329

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 6. — Bortezomib treatment leads to downregulation of c-FLIP and XIAP in FAB M4/M5 AML cells. Cells were treated with (A) 7 nM (ML-1), 16 nM (OCI AML2) or 25 nM (OCI AML3) bortezomib or (B) 2 nM (HL60, KG-1), 4 nM (HL60) or 8 nM (Kasumi) bortezomib for 18 h after which cell lysates were harvested and analyzed for c-FLIP and XIAP expression by Western blotting. Expression of actin was detected to serve as a loading control.