Table 1.
Plasmodium strain | Host mouse genotype (mAb administration) | Mouse background | Features of host mice after the Plasmodium infection | Reference |
---|---|---|---|---|
P. yoelii 17XNL | IFN-γ KO | B6/129 | Delayed elimination of parasites and had higher parasitemia | van der Heyde et al. (37) |
P. chabaudi adami 556KA | IFN-γ KO | B6/129 | Delayed elimination of parasites and had higher parasitemia | van der Heyde et al. (37) |
P. chabaudi chabaudi AS | IFN-γR KO IFN-γ KO | B6/129 B6 | Higher parasitemia during second peak. 77% of the infected mice died Male mice developed higher parasitemia. Female mice delayed elimination of parasites and had higher parasitemia. 100% Male and 40% female mice died | Favre et al. (36), Su and Stevenson (39) |
P. berghei XAT | WT (anti-IFN-γ mAb) IFN-γ KO | CBA B6 | Could not eliminate parasites and died | Waki et al. (33), Yoneto et al. (35) |
P. berghei NK65 | WT (anti-IFN-γ mAb) WT (anti-IFN-γ mAb) | CBA B6 | P. berghei NK65 is a high virulent strain and induces liver injury in CBA and B6 mice. The mAb-treated mice prolonged survival | Waki et al. (33), Yoshimoto et al. (34) |
P. berghei ANKA | IFN-γR KO IFN-γ KO IFN-γR KO | CBAB6B6/129 | P. berghei ANKA is a high virulent strain and induces neurological symptoms in 129 and B6 mice. The KO mice prolonged survival and did not developed neurological symptoms | Amani et al. (38), Villegas-Mendez et al. (61), Rudin et al. (94) |
IFN, interferon; IFN-γR, IFNγ receptor; mAb, monoclonal antibody.