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Conceptual framework for a theoretic role of glycemic variability in the acutely ill patient. Glycemic variability may be influenced by patient-specific factors such as acute illness, duration of diabetes, presence of comorbidities, and other medications. Sustained hyperglycemia, hypoglycemia, and glycemic variability may lead to endothelial dysfunction and oxidative stress, which in turn contribute to end-organ dysfunction and death.
