TABLE 2.
ART-Treated HIV-Infected Subjects Have Hyperreactive Platelets
| Baseline % Platelet Aggregation |
1 Week Aspirin % Platelet Aggregation |
||||||
|---|---|---|---|---|---|---|---|
| HIV-1 | Control | P | HIV-1 | Control | P | ||
| ADP | 0.4 uM 300s | 4.0 (1.0–12.0) | 0.0 (0.0–1.5) | <0.0001 | 3.0 (0.0–9.0) | 0.0 (0.0–2.0) | 0.0171 |
| 0.4 uM MAX | 11.3 (6.6–44.4) | 6.4 (2.6–10.1) | 0.0027 | 9.4 (3.1–13.9) | 6.3 (2.9–10.0) | 0.1753 | |
| 1 uM 300s | 35.0 (10.0–87.0) | 27.5 (3.2–88.3) | 0.5629 | 13.0 (6.0–20.1) | 9.0 (4.8–13.4) | 0.0905 | |
| 1 uM MAX | 59.3 (25.8–88.3) | 43.0 (25.6–91.5) | 0.9481 | 28.4 (17.8–41.1) | 34.7 (25.7–40.1) | 0.1766 | |
| 2 uM 300s | 81.0 (42.0–92.0) | 88.0 (73.0–93.0) | 0.2803 | 36.0 (13.0–51.0) | 32.5 (21.0–47.0) | 0.8726 | |
| 2 uM MAX | 84.3 (52.5–93.5) | 89.3 (77.2–94.5) | 0.3042 | 52.5 (41.4–65.7) | 59.2 (50.9–63.7) | 0.1533 | |
| COL | 0.05 ug/mL 300s | 2.0 (0.0–7.5) | 0.0 (0.0–0.5) | 0.0003 | 3.0 (0.3–6.0) | 1.0 (0.0–4.3) | 0.0765 |
| 0.05 ug/mL MAX | 5.6 (3.9–12.4) | 3.2 (1.8–6.2) | 0.0011 | 8.4 (3.5–11.3) | 4.7 (3.5–6.5) | 0.0790 | |
| 0.2 ug/mL 300s | 8.5 (0.0–83.5) | 6.0 (0–84.0) | 0.9770 | 5.0 (2.0–9.9) | 3.0 (0.5–5.0) | 0.0631 | |
| 0.2 ug/mL MAX | 12.6 (4.3–88.2) | 11.3 (4.0–88.6) | 0.8485 | 8.1 (4.8–13.9) | 6.7 (4.0v8.9) | 0.1245 | |
| 1 ug/mL 300s | 84.0 (80.0–88.0) | 87.0 (83.8–89.0) | 0.1247 | 20.5 (12.50–31.5) | 16.0 (7.0–24.5) | 0.1272 | |
| 1 ug/ml MAX | 87.4 (81.4–90.7) | 90.0 (86.8–91.5) | 0.1009 | 26.1 (16.0–33.3) | 18.9 (10.9–28) | 0.1087 | |
| EPI | 0.1 uM 300s | 22.0 (9.0–80.0) | 16.0 (7.6–46.8) | 0.1508 | 9.5 (6.0–17.0) | 11.0 (7.8–13.6) | 0.7999 |
| 0.1 uM MAX | 81.2 (17.0–91.3) | 78.8 (13.0–90.7) | 0.6715 | 17.1 (11.4–25.8) | 16.9 (13.2–21.8) | 0.8060 | |
| 0.4 uM 300s | 79.5 (36.8–89.0) | 81.0 (68.5–85.5) | 0.7179 | 19.5 (13.3–30.3) | 22 (13.5–26.5) | 0.7446 | |
| 0.4 uM MAX | 89.2 (81.4–95.2) | 90.6 (87.3–93.4) | 0.6971 | 27.9 (19.6–42.7) | 28.9 (20.8–37.6) | 0.9436 | |
| 2 uM 300s | 83.0 (76.3–91.5) | 88.8 (84.0–90.5) | 0.1357 | 32.5 (23.0–53.0) | 36.5 (23.8–44.0) | 0.8058 | |
| 2 uM MAX | 86.6 (78.3–93.4) | 91.7 (88.1–93.8) | 0.0803 | 44.9 (30.4–65.7) | 44.1 (32.3–54.4) | 0.9539 | |
| AA | 150 uM 300s | 5.0 (1.5–13.8) | 0.0 (0.0–4.0) | 0.0033 | 7.0 (4.0–9.0) | 4.0 (1.0–7.0) | 0.0214 |
| 150 uM MAX | 54.9 (8.2–89.9) | 7.4 (2.7–34.6) | 0.0028 | 9.8 (5.8–16.6) | 6.1 (4.4–9.2) | 0.0036 | |
| 1500 uM 300s | 88.5 (83.5–90.0) | 88.0 (85.0–90.0) | 0.8790 | 18.0 (10.5–23.0) | 9.5 (4.8–15.0) | 0.0044 | |
| 1500 uM MAX | 90.4 (86.3–93.0) | 91.5 (89.0–92.9) | 0.4877 | 20.8 (12.6–49.2) | 12.0 (7.2–23.9) | 0.0062 | |
| SPA | 300s | 3.0 (1.0–8.0) | 2.5 (0.4–4.0) | 0.1390 | 2.0 (1.0–6.0) | 3.0 (2.0–5.3) | 0.4681 |
| MAX | 7.9 (4.6–11.8) | 4.9 (2.3–8.5) | 0.0445 | 7.3 (4.8–13.4) | 6.2 (4.2–8.5) | 0.2223 | |
ADP, adenosine diphosphate; COL, collagen; EPI, epinephrine.