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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Free Radic Biol Med. 2013 May 31;63:421–431. doi: 10.1016/j.freeradbiomed.2013.05.036

Figure 2. VEGFR-2 inhibition induces oxidative stress and apoptosis that are prevented by treatments with NAC.

Figure 2

(A), NB cultured neurons were treated without and with SU1498 (10 μM) alone or in combination with NAC during the final 24 hr of the 48 hr incubation. Lysates were analyzed by western blotting for the levels of HO-1 and cleaved caspase-3 (arrow). Data are quantified relative to the vehicle control. *(P<0.05) indicates a significant difference between SU1498 versus NAC/SU1498 for HO-1 and **(P<0.01) indicates a significant difference between SU1498 versus control or NAC for HO-1 and Caspase-3. ***(P<0.001) indicates a significant difference between SU1498 versus NAC/SU1498 for Caspase-3. (B), Neurons cultured as in (A) were analyzed for cell viability as described in Figure 1C. ***(P<0.001) indicates a significant difference between SU1498 versus control or NAC/SU1498.