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. 2012 Nov 7;62(9):1340–1346. doi: 10.1136/gutjnl-2012-302553

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

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Median reduction of hepatitis C virus (HCV)-RNA levels (log copies/ml) after administering pegylated interferon α to chimeric mice having human hepatocytes containing various single nucleotide polymorphisms around the IL28B gene as favourable (rs8099917 TT) and unfavourable (rs8099917 TG) genotypes. Data are represented as mean+SD. Chimeric mice infected with a) serum A (n=7; favourable genotype, n=6; unfavourable genotype), (B) serum B (n=2, each genotype), and (C) serum C (n=2, each genotype). All serum samples were obtained from HCV-1b patients.