Table 3.

Dosage and time schedule of pegIFN-α2a* treatment for HCV genotype 1b infected chimeric mice

				Dose
Donor hepatocytes†	No of chimeric mice	Inoculum	Test compound	Level (μg/kg)	Concentrtion (μg/ml)	Volume (ml/kg)	Frequency
A	3	Serum A	Peg-IFN-α2a	30	3	10	Day 0, 3, 7, 10
B	4	Serum A	Peg-IFN-α2a	30	3	10	Day 0, 3, 7, 10
C	3	Serum A	Peg-IFN-α2a	30	3	10	Day 0, 3, 7, 10
D	3	Serum A	Peg-IFN-α2a	30	3	10	Day 0, 3, 7, 10
A	2	Serum B	Peg-IFN-α2a	30	3	10	Day 0, 3, 7, 10
C	2	Serum B	Peg-IFN-α2a	30	3	10	Day 0, 3, 7, 10
A	2	Serum C	Peg-IFN-α2a	30	3	10	Day 0, 3, 7, 10
C	2	Serum C	Peg-IFN-α2a	30	3	10	Day 0, 3, 7, 10

*Pegasys; Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.

†The IL28B genetic variation of the donor hepatocytes was indicated in table 2.

HCV, hepatitis C virus; peg-IFN-α, pegylated interferon α.