Table 2.
Disease characteristics and course of patients with disease flare after discontinuation of TKI. TKI (tyrosine kinase inhibitor)
| Sex & Smoking |
EGFR
mutation |
T790M | Sites of Disease |
Days off TKI |
Description of Flare |
|---|---|---|---|---|---|
| 47 Female Never smoker |
Exon 19 Deletion |
No | Pleura Brain Liver |
21 days | Progressive liver metatases with liver failure and death |
| 64 Female Never smoker |
Exon 19 Deletion |
No | Pleura | 21 days | Dyspnea |
| 53 Female Never smoker |
Exon 19 Deletion |
Unknown | Pleura Brain Bone |
14 days | CNS progression |
| 60 Female Never smoker |
Exon 21 L858R |
Unknown | Pleura Brain Bone |
7 days | Hypoxia and Bone pain |
| 34 Male Never smoker |
Exon 19 Deletion |
No | Pleura Brain |
11 days | Dyspnea |
| 27 Female Never smoker |
Exon 19 Deletion |
Unknown | Brain Liver Bone Pericardium |
11 days | Bone pain |
| 47 Female Never smoker |
Exon 21 L858R |
Yes | Pleura | 7 days | New leptomeningeal disease |
| 49 Male Never smoker |
Exon 19 Deletion |
Yes | Bone Liver |
7 days | New brain metastases, seizure |
| 61 Female Never smoker |
Exon 21 L858R |
No | Pleura Brain Liver Peritoneum |
3 days | Abdominal pain |
| 45 Female Never smoker |
Exon 19 Deletion |
Yes | Pleura Bone |
8 days | New leptomeningeal carcinomatosis, seizure, death |
| 46 Female Former smoker |
Exon 19 Deletion |
Yes | Pleura Liver Bone |
12 days | Epidural progression |
| 62 Female Never smoker |
Exon 19 Deletion |
Yes | Pleura Bone Pericardium |
8 days | Pericardial tamponade, death |
| 42 Female Never smoker |
Exon 18 E709A & G719A |
Yes | Pleura Bone |
8 days | Acute pleural effusion requiring drainage |
| 67 Female Former smoker |
Exon 21 L858R |
No | Pleura Brain |
8 days | Dyspnea |